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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus typeI (HIV-1).This observation indicates that the immune responses elicited by natural HIV-1 infection may play a roleThus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thaninsufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 346-350 doi: 10.1007/s11684-010-0102-x

Abstract: FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990sFew studies about the natural history of HIV infection in these patients were performed.A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in ShangcaiThis is the first large-scale retrospective study on the natural history of HIV infection in FPDs in

Keywords： human immunodeficiency virus (HIV)     former plasma donor     natural history     China    

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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: Precise identification of HIV transmission among populations is a key step in public health responsesHowever, the HIV transmission network is usually difficult to determine.HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, andare increasingly used to identify transmission networks among populations, reconstruct the history of HIVspread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations,

Keywords： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

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Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip Article

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Engineering 2015, Volume 1, Issue 3,   Pages 324-335 doi: 10.15302/J-ENG-2015072

Abstract:

Viral load measurements are an essential tool for the long-term clinical care of human immunodeficiencyvirus (HIV)-positive individuals.poor healthcare infrastructure, including parts of the world that are disproportionately affected by HIVperform reverse-transcription loop-mediated isothermal amplification (RT-LAMP) on minimally processed HIV-spikedscaled up for the determination of viral load from a finger prick of blood in the clinical care of HIV-positive

Keywords： human immunodeficiency virus (HIV)     viral load     loop-mediated isothermal amplification     smartphone     point-of-care    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: antiretroviral therapy (cART) has significantly improved the life expectancy of people living with humanimmunodeficiency virus (HIV), but it has many side effects such as lipodystrophy (LD), hepatic steatosisNucleoside reverse transcriptase inhibitors (NRTIs) could damage the mitochondria by inhibiting the humanNRTIs could induce the hypervariable region (HV) mutations of the D loop of mitochondria in Chinese HIV

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of

Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 192-198 doi: 10.1007/s11684-010-0039-0

Abstract: parasites in a HIV/AIDS highly endemic area in China.Blood examination was performed for the HIV infection detection and anemia test.the co-infection rates of HIV and , and HIV and spp. were 19.57% and 13.04%, respectively.A significant difference of spp. infection rate was found between HIV-positive group (13.04%) and HIV-negativehigher than that in the HIV-negatives, and children and women had higher anemia prevalence.

Keywords： human immunodeficiency virus (HIV)     acquired immunodeficiency syndrome (AIDS)     co-infection     intestinal    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelial    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininSimilarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directedHere we review what is known about the human humoral immune response to vaccination and infection withunderstanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 459-462 doi: 10.1007/s11684-009-0084-8

Abstract: The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in women

Keywords： cervical cancer     human papilloma virus     cervical intraepithelial neoplasia    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract: syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virusWe also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebolavirus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral

Keywords： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis B viruslevels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressing hepatitis B virus

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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Study on factors affecting TB/HIV co-infection in four counties of China

Shi-Ming CHENG MD, Yu-Ji LAI MS, Er-Yong LIU MS, Lin ZHOU MD, Xue-Jing WANG MS, Qiu-Lan CHEN MS, Dong-Ming LI MS, Ning WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 185-191 doi: 10.1007/s11684-010-0040-7

Abstract: The factors affecting case detection of tuberculosis (TB)/human immunodeficiency virus (HIV) co-infectionand HIV institutions were selected.HIV test among TB patients and TB examination among people living with HIV/acquired immunodeficiencywho received HIV testing.TB checks should be conducted for HIV/AIDS patients.

Keywords： tuberculosis/acquired immunodeficiency syndrome     dual infection     prevention and control     case detection    

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correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 584-595 doi: 10.1007/s11684-021-0844-7

Abstract: In this study, a recombinant FVIII cDNA encoding a human/rat hybrid FVIII with an enhanced procoagulantpotential for adeno-associated virus (AAV)-delivered gene therapy was developed.Plasmids containing human FVIII heavy chain (hHC), human light chain (hLC), and rat light chain (rLC)

Keywords： hemophilia A     adeno-associated virus (AAV)     human/rat hybrid factor VIII     gene therapy     dual chain strategy    

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Pregnancy outcome analysis of HIV infected women in Xinjiang， 2010—2013

Shawuli∙Ailika,Aibibai∙Maimaitiming,Wang Xiaojun

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 50-52

Abstract:

To understand pregnancy outcomes of HIV infected women in Xinjiang.We collected and analyzed 2256 HIV infected women reported by PMTCT management information reportingunemployed), first marriage( 56.12 %), remarried ( 37.19%). 2 times or more pregnancies ( 69.68%), 316 HIVinfected women didn’t stop pregnancy after knowing their HIV infected status, accounts for 14.01%The research suggest that we should strengthen counseling and services and contraception for HIV-infected

Keywords： HIV infected pregnant women     unwilling pregnancy     reproductive health    

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Title Author Date Type Operation

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Journal Article

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article

Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of

Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Journal Article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

Study on factors affecting TB/HIV co-infection in four counties of China

Shi-Ming CHENG MD, Yu-Ji LAI MS, Er-Yong LIU MS, Lin ZHOU MD, Xue-Jing WANG MS, Qiu-Lan CHEN MS, Dong-Ming LI MS, Ning WANG MD,

Journal Article

correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human

Journal Article

Pregnancy outcome analysis of HIV infected women in Xinjiang， 2010—2013

Shawuli∙Ailika,Aibibai∙Maimaitiming,Wang Xiaojun

Journal Article